Summary: Myxomatous valve disease (MVD) can lead to cardiac dysfunction and heart failure. yet medical therapies are lacking. C-C chemokine receptor type 2 (CCR2)+ immune cell infiltration promotes mitral valve inflammation in a Marfan syndrome (MFS) mouse model. The CCR2 genetic knockout reduces inflammation with downregulated proteases and improved extracellular matrix integrity. https://www.atlanticknifers.shop/product-category/handwarmer/